EC Number   |
Application |
Reference |
|---|
   3.4.21.B6 | medicine |
blood-borne RT-PCR amplification of prostasin transcripts may provide an early diagnosis of disseminated disease in patients with organ-confined carcinoma |
673905 |
| 3.4.21.B6 | medicine |
exogenous expression of prostasin can protect suckling mice from life-threatening DENV-2 infection. Inhibition of DENV propagation by prostasin is due to reducing expression of epithelial growth factor receptor, leading to suppression of the Akt/NF-kappaB-mediated cyclooxygenase-2 signaling pathway |
754338 |
| 3.4.21.B6 | medicine |
genetic variation of the prostasin gene may be implicated in the development of hypertension in youths |
690329 |
| 3.4.21.B6 | medicine |
is a major regulator of epithelial Na+ channel-mediated Na+ current, airway prostasin is a target for therapeutic inhibition to normalize ion current in cystic fibrosis airway |
671251 |
| 3.4.21.B6 | medicine |
matriptase and prostasin mRNA levels are significantly reduced in colonic tissues from patients with both ulcerative colitis and Crohn's disease |
754145 |
| 3.4.21.B6 | medicine |
mRNA and protein expression of both matriptase and prostasin are rapidly down-regulated in the initiating inflammatory phases of dextran sulfate sodium-induced experimental colitis, and the loss of these proteases precedes the appearance of clinical symptoms. Barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6 |
754145 |
| 3.4.21.B6 | medicine |
patients with dengue fever show relatively low expression of prostasin and compared with healthy individuals and a high correlation of prostasin expression and DENV-2 RNA copy number. Dengue virus infection significantly decreases prostasin RNA levels of in vivo and in vitro models |
754338 |
| 3.4.21.B6 | medicine |
promoter DNA methylation partly causes the prostasin down-regualtion in prostate cancer cell lines |
676929 |
| 3.4.21.B6 | medicine |
prostasin is a tumor marker in ovarian cancer |
708209 |
| 3.4.21.B6 | medicine |
prostasin, matriptase, hepatocyte growth factor activator inhibitor type 1 (HAI-1) and 2, and nexin-1 mRNA abundances are not different in placental tissue between patients with preeclampsia and healthy pregnant women. Prostasin mRNA in placenta correlates directly with nexin-1 and HAI-1 mRNA, but not with matriptase mRNA. Plasma prostasin and placental homogenate prostasin and nexin-1 protein levels do not differ between groups. Preeclamptic patients show significantly elevated levels of prostasin in urine that correlates with urine albumin |
754323 |
