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EC Number Application Commentary Reference
Show all pathways known for 2.8.3.21Display the reaction diagram Show all sequences 2.8.3.21synthesis production of L-carnithine in Escherichia coli. The overexpression of CoA-transferase CaiB and CoA-ligase CaiC leads to an increase in L-carnitine production. Under optimal concentrations of inducer and fumarate yields reach 10- and 50fold, respectively, that obtained for the wild type strain. Low levels of coenzyme A limit the activity of these two enzymes. The glyoxylate shunt and anaplerotic pathways limit the bioprocess since strains carrying deletions of isocitrate lyase and isocitrate dehydrogenase phosphatase/kinase yielded 20-25% more L-carnitine than the control. The deletion of phosphotransacetylase strongly inhibits the bioprocess 728014
Show all pathways known for 2.8.3.21Display the reaction diagram Show all sequences 2.8.3.21synthesis production of L-carnithine in Escherichia coli. When the dilution rate and the initial crotonobetaine concentration are directly changed in the real experimental system to the optimum values, the system a 74% increase in production rate. Development of a model showing control points at reactor operation and molecular levels where conversion and productivity can be increased 727237
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