EC Number |
Application |
Reference |
---|
2.5.1.19 | synthesis |
enzyme is a target for development and synthesis of antimicrobial drugs |
658112, 659285 |
2.5.1.19 | drug development |
protonated enolpyruvylshikimate 3-phosphate (cation) intermediate as potential target for inhibitor design |
678255 |
2.5.1.19 | biotechnology |
glyphosate tolerance in bacteria |
-, 681333 |
2.5.1.19 | biotechnology |
strain PCC6803 DnaE intein N-terminal and C-terminal splicing domains can reconstitute EPSPS activities and glyphosate resistance in plant |
-, 690523 |
2.5.1.19 | drug development |
differential inhibition of class I and class II EPSPS by tetrahedral reaction intermediate-analogues possibly due to alteration of open-close transition during catalysis and/or upon inhibitor binding but not due to energy differences during complex formation |
-, 690885 |
2.5.1.19 | drug development |
more experimental data needed for effective structure-based drug design |
691936 |
2.5.1.19 | biotechnology |
conferring glyphosate tolerance in transgenic crop plants |
-, 694557 |
2.5.1.19 | agriculture |
Arabidopsis thaliana transgenic plants expressing mutant E145G/N163H/N267S/P318R/M377V/M425T/P438L grow well in presence of 0.75 mM glyphosate, whereas Arabidopsis thaliana plants expressing wild-type enzyme grow only in presence of 0.25 mM glyphosate |
721350 |
2.5.1.19 | agriculture |
transgenic Arabidopsis thaliana plants expressing the enzyme from Halothermothrix orenii are more resistant to glyphosate exposure than transgenic plants expressing the Escherichia coli enzyme and control plants |
-, 721379 |
2.5.1.19 | agriculture |
transgenic Arabidopsis thaliana plants expressing the enzyme from Pseudomonas fluorescens are more resistant to glyphosate exposure compared with wild-type |
723145 |