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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine in cancer cells, enzyme plays a major role in the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Link between enzyme overexpression and dysregulation of membrane composition and functioning in tumor cells 660856
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine triclosan suppresses mammary carcinogenesis by inhibiting enzyme 661434
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine anorectic effect of C75 is independent of its inhibition of enzyme in the hypothalamus 661661
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85nutrition animals fed with semipurified diets containing either 1% w/w corn oil or 10% each of beef tallow, corn oil, perilla oil, and fish oil. Enzyme activity is reduced in the polyunsaturated fat-fed group in the order of fish oil, perilla oil, and corn oil 662067
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine androgen-independent expression of enzyme in oral SSC cells, enzyme activity is necessary for their proliferation 663001
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine TRAMP mouse prostate adenocarcinoma cells show high enzyme expression and activity compared to nontransgenic littermates. Inhibition of enzyme expression and activity results in dose-dependent reduction in cell survival 663279
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine FAS is a target for drug development against obesity and related diseases, and FAS inhibitors have antitumor activity 671025
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine FAS could be a useful signal for early detection of ulcerative coliti 671198
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine the enzyme is a potential therapeutic target to treat cancer and obesity. Acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors 672604
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.85medicine endogenously synthesized fatty acids do not fulfill a specific function in cancer cells. Cancer cells do not produce fatty acids that are different from those derived from exogenous palmitate, these fatty acids are esterified to the same lipid and phospholipid classes in the same proportions, and their distribution within neutral lipids is not different from untransformed cells. Anoxia increases glycolysis 2-3fold, with no concomitant increase in lipogenesis 736065
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