EC Number   |
Application |
Reference |
|---|
    1.3.5.1 | biotechnology |
a new host-vector system for Mortierella alpina 1S-4, zygomycetes, on the basis of self-cloning for the industrial application of Mortierella transformants is developed. Transformants expressing the Escherichia coli uidA gene encoding beta-glucuronidase by using the mutant H243L as the selectable marker (leading to to carboxin resistance) |
697493 |
| 1.3.5.1 | diagnostics |
mutations of SDH subunit encoding genes are good markers for paraganglioma |
688213 |
| 1.3.5.1 | diagnostics |
SDHB mutations are a marker for a prognostic risk of patients with pheochromocytomas or paragangliomas |
687963 |
| 1.3.5.1 | diagnostics |
succinate dehydrogenase subunits may be candidate susceptibility genes for some phosphatase and tensin homolog (PTEN, tumor suppressor) mutation-negative individuals with Cowden syndrome-like cancers. To address this hypothesis, germline succinate dehydrogenase subunits SDHB-D mutation analysis in 375 PTEN mutation-negative Cowden syndrome /Cowden syndrome -like individuals is performed, followed by functional analysis of identified SDH mutations/variants. Germline SDH mutations/variants occur in a subset of PTEN mutation-negative Cowden syndrome /Cowden syndrome -like individuals and are associated with increased frequencies of breast, thyroid, and renal cancers beyond those conferred by germline PTEN mutations. SDH testing should be considered for germline PTEN mutation-negative Cowden syndrome /Cowden syndrome -like -like individuals, especially in the setting of breast, thyroid, and/or renal cancers |
684284 |
| 1.3.5.1 | medicine |
an SDHB-related pheochromocytoma/paragangliomas patient is presented bearing a SDHB gene mutation with extensive tumor burden, numerous organ lesions, and rapidly growing tumors, which responded extremely well to cyclophosphamide, vincristine, and dacarbazine combination chemotherapy |
697623 |
| 1.3.5.1 | medicine |
mutations in the genes encoding succinate dehydrogenase are associated with hereditary predisposition to pheochromocytoma and paraganglioma. The results support the notion that loss of mitochondrial function alters epigenetic processes and might provide a signature methylation mark for paraganglioma |
700139 |
| 1.3.5.1 | medicine |
no DNA methylation is identified in the promoter regions of the succinate dehydrogenase A, B, C, D and fumarate hydratase genes in 72 breast carcinomas and 10 breast cancer cell lines using methylation sensitive high resolution melting which detects both homogeneous and heterogeneous methylation, implying that that inactivation via DNA methylation of the promoter CpG islands of SDH and fumarate hydratase is unlikely to play a major role in sporadic breast carcinomas |
697001 |
| 1.3.5.1 | medicine |
species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics |
698668 |
| 1.3.5.1 | medicine |
the succinate dehydrogenase iron-sulfur protein is a promising candidate for a partially protective vaccination against Schistosoma, SjSDISP vaccine may primarily play a role in anti-embryonation or anti-fecundity immunity |
-, 690050 |
| 1.3.5.1 | molecular biology |
considering the conservation of amino acids crucial for the SQR activity and the high levels of ROS production from the mitochondrial complex II of the Ascaris suum adult worm together with the absence of complexes III and IV activities in its respiratory chain, it is a good model to examine the reactive oxygen species production from the mitochondrial complex II |
700074 |
