EC Number   |
Application |
Reference |
|---|
    1.3.1.22 | analysis |
assay for evaluating 5alpha-reductase activity in large-scale clinical studies using the S9 fraction obtained by centrifugation of the homogenate supernatant at 9000 g for 30 min and gas chromatography-mass spectrometry |
725859 |
| 1.3.1.22 | analysis |
radiosubstrate in vitro incubation method for the determination of 5alpha-reductase type 1 activity using rat liver microsomes as an enzyme source |
710704 |
| 1.3.1.22 | medicine |
30 min incubation with dutasteride results in the lowest apparent Ki values overall and the lowest variation, significant for designing protocols for treatment and/or chemoprevention of prostatic diseases |
675475 |
| 1.3.1.22 | medicine |
5alpha reductase inhibitors decrease prostate volume and induce atrophy and apoptosis in benign prostatic epithelium |
688719 |
| 1.3.1.22 | medicine |
5alphaR1 is increased and 5alphaR2 is decreased during development of prostate cancer, increased expression of both isozymes in recurrent and metastatic cancer, both isozymes may be important in the development and progression of prostate cancer |
676930 |
| 1.3.1.22 | medicine |
analysis of single-type nucleotide polymorphisms in isoforms SRD5A1 and SRD5A2. Haplotypes within both genes are associated with homocystic ovary syndrome risk. V89L variant of isoform SRD5A2 is associated with protection against homocystic ovary syndrome. Haplotypes in SRD5A1 are also associated with the degree of hirsutism in affected women |
669624 |
| 1.3.1.22 | medicine |
assay for evaluating 5alpha-reductase activity in large-scale clinical studies using the S9 fraction obtained by centrifugation of the homogenate supernatant at 9000 g for 30 min and gas chromatography-mass spectrometry |
725859 |
| 1.3.1.22 | medicine |
functional variation within isoform SRD5A2 influences, in a sex-specific way, the severity of post-traumatic stress symptoms and risk for diagnosis of post-traumatic stress disorder. There is a significant sex-dependent effect of genotype for the V89L variant in male but not female subjects on symptoms |
723907 |
| 1.3.1.22 | medicine |
higher expression of 5alpha-R2, which is considered a masculinizing enzyme, in the female versus male central nervous system, sexual dimorphism in the regulation of 5alpha isozymes by dihydrotestosterone |
676162 |
| 1.3.1.22 | medicine |
morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase the following chronic morphine administration |
726046 |
