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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.124diagnostics the enzyme is a clinically relevant biomarker for castration-resistant prostate cancer (CRPC) 759825
Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.124medicine mitochondrial 2,4-dienoyl-CoA reductase is a clinically relevant biomarker for castration-resistant prostate cancer. DECR1 participates in redox homeostasis by controlling the balance between saturated and unsaturated phospholipids. DECR1 knockout induces ER stress and sensitizes castration-resistant prostate cancer cells to ferroptosis. In vivo, DECR1 deletion impairs lipid metabolism and reduces castration-resistant prostate cancer tumor growth 759825
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