EC Number   |
Natural Substrates |
|---|
   5.4.99.B22 | 23S rRNA uridine2457 |
RluE forms a highly conserved pseudouridine during ribosome biogenesis |
| 5.4.99.B22 | KAR2 mRNA uridine |
- |
| 5.4.99.B22 | mitochondrial tRNAPhe uridine39 |
- |
| 5.4.99.B22 | more |
Pus1p catalyzes the formation of pseudouridines in several positions and in a number of different tRNA species |
| 5.4.99.B22 | more |
extensive, regulated pseudouridylation of Toxoplasma mRNA with evidence for 1669 and 394 sites of pseudouridylation in tachyzoite and bradyzoite mRNAs, respectively. The distribution of Us and Psis is significantly different between the three regions of the transcript. Pseudouridylation is underrepresented in the 3'-UTR. At least in tachyzoites, TgPUS1-dependent Psis are distributed within the codon comparably toTgPUS1-independent Psis |
| 5.4.99.B22 | more |
for tRNA and Pus7, many known sites and their associated modifiers are identified, including Pus1-mediated Psi sites at positions 26-28 in several tRNAs, Pus7-dependent sites at position 13 of glutamate tRNA, Pus9-dependent site in mitochondrial aspartate tRNA at position 32, and Deg1-dependent sites at positions 37-38 in several tRNAs. Pseudouridylation in ncRNAs at sites of inter or intra-molecular interactions |
| 5.4.99.B22 | more |
Pus1p is the only pseudouridine synthase in Saccharomyces cerevisiae that is active on U2 snRNA at position 44. Yeast U2 snRNA is normally pseudouridylated at positions 35, 42, and 44 |
| 5.4.99.B22 | RPL11a mRNA uridine68 |
the Pus1 enzyme is necessary and sufficient for pseudouridylation of RPL11a mRNA |
| 5.4.99.B22 | TEF1 mRNA uridine239 |
- |
| 5.4.99.B22 | tRNA uridine13 |
- |
