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Results 1 - 4 of 4

EC Number	Natural Substrates	Commentary (Nat. Sub.)
4.2.99.B1	more	reaction is part of the DNA base excision repair BER
4.2.99.B1	more	removal of the 5'-deoxyribose phosphate group is a pivotal step in the base excision repair (BER) pathway in vivo
4.2.99.B1	more	catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. According to the lyase catalytic mechanism, the epsilon-amino group of a catalytic lysine reacts with C1'-carbon of an AP site producing a Schiff base intermediate
4.2.99.B1	more	catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. The reaction mechanism of the lyase reaction involves a transient covalent enzyme-DNA intermediate in the form of a Schiff base connecting Lys72 of the enzyme with the 5'-dRP moiety. The Schiff base intermediate is resolved via a beta-elimination reaction, initiated by abstraction of a C2'-H atom from the 5'-deoxyribose phosphate (5'-dRP) moiety

Results 1 - 4 of 4

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Release 2023.1 (January 2023)