EC Number   |
Natural Substrates |
|---|
   3.5.4.36 | 5-methylcytosine in single-stranded DNA + H2O |
Apobec1 has 5-methylcytosine deaminase activity, resulting in a thymine base opposite a guanine. If this mismatch is repaired, a methylated cytosine is replaced by an unmethylated one. If it is not repaired, it results in a cytosine -> thymine transition mutation. Apobec1, and perhaps other members of this protein family play a role in epigenetic reprogramming |
| 3.5.4.36 | cytosine in RNA + H2O |
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo |
| 3.5.4.36 | cytosine in RNA + H2O |
transcriptome-wide sequencing reveals numerous APOBEC1 mRNA editing targets in transcript 3' untranslated regions, a molecular mechanism that suggests additional roles for APOBEC1 beyond its function in apolipoprotein regulation |
| 3.5.4.36 | cytosine in single-stranded DNA + H2O |
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo |
| 3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
- |
| 3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
APOBEC1, catalytic component of an RNA-editing complex, transports the complementing specificity factor ACF to and from the nucleus as cargo. Expression of APOBEC1 alone edits apoB RNA and generates a substrate for nonsense-mediated decay. The APOBEC1/ACF editing complex protects the edited apoB RNA from nonsense-mediated decay and transports the RNA to the cytoplasm for translation |
| 3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
apolipoprotein (apo)B mRNA editing is mediated by a multiprotein editosome complex. Apobec-1 is the catalytic component of this complex. ABBP-1 (apobec-1-binding protein-1) is an apobec-1-interacting protein that may play an important role in apoB mRNA editing |
| 3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
apolipoprotein B mRNA editing at nucleotide 6666 converts cytidine to uridine, transforming the codon for glutamine-2153 to a termination codon |
| 3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1-/- mice |
| 3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene. The shorter form, apo B48, arises by posttranscriptional RNA editing whereby cytidine deamination produces a UAA termination codon |
