EC Number   |
Natural Substrates |
|---|
   3.4.24.29 | Bap + H2O |
a surface-anchored protein |
| 3.4.24.29 | cathelicidin LL-37 + H2O |
human antimicrobial peptide. Enzyme production by Staphylococcus aureus contributes to its resistance to the innate immune system of humans mediated by LL-37 |
| 3.4.24.29 | Collagen + H2O |
the enzyme cleaves collagen into peptide fragments that can support Staphylococcus aureus growth under nutrient-limited conditions |
| 3.4.24.29 | complement component C3 + H2O |
aureolysin cleaves purified C3 specifically in the alpha-chain, close to the C3 convertase cleavage site, yielding active C3a and C3b. In serum, the aureolysin-generated C3b is further degraded by host factors |
| 3.4.24.29 | Galectin-3 + H2O |
the enzyme has galectin-3-processing capacity. It cleaves human galectin-3 (a beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense) into mostly higher-molecular-mass fragments, suggesting that it primarily digested the more distant parts of the N-terminal collagen-like domain |
| 3.4.24.29 | more |
activates the precursor of another protease secreted by the same organism, staphylococcal protease |
| 3.4.24.29 | more |
the aur null mutant strain causes the same immune reaction in mice as the wild-type strain, overview |
| 3.4.24.29 | more |
Aureolysin collaborates with host factors to inactivate C3b |
| 3.4.24.29 | SspA zymogen + H2O |
aureolysin is essential for activation of SspA zymogen, but the first step in processing of the N-terminal propeptide requires autocatalytic intramolecular cleavage at glutamine, aureolysin then processes at Leu58 and then Val69 to produce the first active molecules of mature SspA, which then feed back to promote efficient autocatalytic intermolecular processing of remaining zSspA at Glu65, mechanism, overview |
