EC Number   |
Natural Substrates |
|---|
   3.4.22.B72 | (SUMO-2)-nucleophosmin 1 conjugate + H2O |
SENP3 as an essential factor for ribosome biogenesis. It is suggested that deconjugation of SUMO2 from nucleophosmin 1 (NPM1) by SENP3 is critically involved in 28S rRNA maturation |
| 3.4.22.B72 | (SUMO-2)-p300 protein + H2O |
removing SUMO2/3 from p300 enhances its binding to HIF-1alpha. SENP3 is a redox sensor that regulates hypoxia-inducible factor-1alpha transcriptional activity under oxidative stress through the de-SUMOylation of p300 |
| 3.4.22.B72 | (SUMO-2/3)-promyelocytic leukemia protein + H2O |
SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress |
| 3.4.22.B72 | (SUMO2)-Borealin protein + H2O |
Borealin is dynamically modified by SUMO2/3 during mitosis |
| 3.4.22.B72 | more |
SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species |
| 3.4.22.B72 | SUMOylated FOXC2 + H2O |
deSUMOylation by enzyme SENP3 |
| 3.4.22.B72 | SUMOylated GTPase Drp1 + H2O |
the substrate is a key target for SENP3-mediated deSUMOylation |
| 3.4.22.B72 | SUMOylated RbBP5 + H2O |
deSUMOylation by enzyme SENP3, the protein is part of SET1/MLL complexes |
