EC Number   |
Natural Substrates |
|---|
   3.4.14.1 | more |
- |
| 3.4.14.1 | more |
,n high affinity interaction between heparin and prochymase allows the 2 residue propeptide to be cleaved by dipeptidylpeptidase I |
| 3.4.14.1 | more |
cathepsin C gene is a direct target for induction by interferon regulatory factor-8 |
| 3.4.14.1 | more |
cathepsin C has a broad substrate specificity being able to hydrolyse out nearly every possible dipeptide unit, with the exception of those containing basic amino acids (Arg or Lys) at N-terminal position or Pro on either side of the scissile bond |
| 3.4.14.1 | more |
cathepsin C is required for granzyme B activation in unstimulated human natural killer cells. However in vitro activation of Papillon-Lefevre syndrome natural killer cells with interleukin-2 restores cytolytic function and granzyme B activity by a cathepsin C-independent mechanism |
| 3.4.14.1 | more |
cathepsin C may stimulate the sorting to the lysosome, at least in part, contributing to the degradation of intestinal alkaline phosphatase in Caco-2 cells, the propeptide of cathepsin C interacts with heat shock cognate protein 70 which is required for a step in chaperone-mediated lysosomal protein degradation |
| 3.4.14.1 | more |
dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation, the enzyme is important for asexual proliferation |
| 3.4.14.1 | more |
DPPI activates granule-associated serine proteases, several of which play important roles in host responses to bacterial infection. DPPI is a key regulator of survival from septic peritonitis |
| 3.4.14.1 | more |
DPPI and neutrophils play a critical role in Sendai virus-induced asthma phenotype as a result of a DPPI-dependent neutrophil recruitment and cytokine response |
| 3.4.14.1 | more |
enzyme is involved in intracellular degradation of proteins |
