EC Number   |
Natural Substrates |
|---|
   3.1.22.1 | DNA + H2O |
the enzyme in macrophages appears to be responsible for destroying the nuclear DNA expelled from erythroid precursor cells |
| 3.1.22.1 | DNA + H2O |
ethanol stress on ARPE-19 cells can induce a pathway which is a form of programmed cell death with characteristics of both apoptosis and necrosis, possibly by triggering conversion of leukocyte elastase inhibitor LEI to L-DNase II |
| 3.1.22.1 | DNA + H2O |
it is proposed that DNase II together with the Chk2, p53, and p21 pathway forms a genetic barrier blocking the replication of potentially harmful DNA introduced via apoptotic bodies, thereby preventing transformation and malignant development |
| 3.1.22.1 | DNA + H2O |
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration |
| 3.1.22.1 | DNA + H2O |
- |
| 3.1.22.1 | DNA + H2O |
induces DNA digestion during apoptosis |
| 3.1.22.1 | DNA + H2O |
prefers to cut purine-rich steps in duplex-DNA, will also attack heat-denatured and single-stranded substrates |
| 3.1.22.1 | DNA + H2O |
cleaves DNA in co-ordination with other nucleases to produce internucleosomal degradation |
| 3.1.22.1 | DNA + H2O |
involvement in recombination, replication and degradation of DNA |
| 3.1.22.1 | DNA + H2O |
directed into the secretory pathway |
