EC Number   |
Natural Substrates |
|---|
    2.7.2.3 | ADP + 1,3-bisphosphoglycerate |
- |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
- |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
key enzyme in glycolysis |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
energy charge is the most important factor in regulating the 2 forms of PGK |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
responsible for production of ATP during glycolysis |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
key enzyme of anaerobic glycolysis in Plasmodium falciparum |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
the enzyme favors the forward reaction |
| 2.7.2.3 | ADP + 3-phospho-D-glyceroyl phosphate |
the reaction occurs at 70°C |
| 2.7.2.3 | ATP + 3-phospho-D-glycerate |
- |
| 2.7.2.3 | ATP + 3-phospho-D-glycerate |
the enzyme is required for ATP generation in the terminal stage of the glycolytic pathway. Important role of PGK in synaptic transmission. Disrupted phosphoglycerate kinase in nubian mutants causes altered ATP generation in nubian animals. Brain extracts show a threefold reduction in resting ATP levels compared with controls. Disruption of ATP generation in nubian animals is accompanied by temperature-dependent defects in neuronal activity with initial seizure activity, followed by an activity-dependent loss of synaptic transmission. Nubian mutants also diaplay structural defects at the synapse, with larger varicosity size but normal varicosity number |
