EC Number   |
Natural Substrates |
|---|
    2.1.1.4 | more |
in pineal glands isolated in the morning 4 h magnetic field exposure changes melatonin release by affecting the signal transduction pathway leading from the norepinephrine receptor to N-acetyltransferase and hydroxyindole-O-methyltransferase and not via a direct effect at the enzyme levels |
| 2.1.1.4 | more |
caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. COMT is a multifunctional enzyme methylating a diverse array of substrates, including phenylpropanoids, flavonoids, and arylalkylamines |
| 2.1.1.4 | more |
caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. The ASMT activity (Vmax/Km) of OsCOMT is 609fold higher than that of rice ASMT1 |
| 2.1.1.4 | more |
the AtASMT protein catalyzes the conversion of N-acetylserotonin to melatonin and serotonin to 5-methoxytryptamine, respectively. The enzyme exhibits no caffeic acid O-methyltransferase activity, suggesting that its function is highly specific to melatonin synthesis |
| 2.1.1.4 | more |
the enzyme also catalyzes the conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate |
| 2.1.1.4 | N-acetylserotonin + S-adenosyl-L-methionine |
- |
| 2.1.1.4 | N-acetylserotonin + S-adenosyl-L-methionine |
formation of the hormone melatonin |
| 2.1.1.4 | S-adenosyl-L-methionine + N-acetylserotonin |
- |
| 2.1.1.4 | S-adenosyl-L-methionine + N-acetylserotonin |
the enzyme is involved in melatonin biosynthesis in egg yolk, overview |
| 2.1.1.4 | S-adenosyl-L-methionine + serotonin |
enzyme AtASMT also O-methylates serotonin to produce 5-methoxytryptamine |
