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Results 1 - 10 of 13

EC Number	Natural Substrates	Commentary (Nat. Sub.)
1.14.13.128	7-methylxanthine + O2 + NAD(P)H + H+	-
1.14.13.128	7-methylxanthine + O2 + NADH + H+	-
1.14.13.128	caffeine + O2 + NADH + H+	-
1.14.13.128	more	caffeine, paraxanthine, and theobromine are not demethylated by the enzyme
1.14.13.128	more	enzyme NdmA catalyzes NADH-dependent N1-demethylation of caffeine to theobromine and theophylline to 3-methylxanthine, and subsequently to 7-methylxanthine, and xanthine. Theobromine is the major product due to highly selective N1-demethylation caffeine by NdmA. But the minor production of paraxanthine from caffeine is due to slight promiscuity of the NdmA towards the N3-position on the caffeine molecule. Direct N-demethylation of caffeine at the N3 position does not occur appreciably with the three N-demethylases involved in caffeine degradation in CBB5
1.14.13.128	1,3,7-trimethylxanthine + O2 + NAD(P)H + H+	i.e. caffeine
1.14.13.128	1,3,7-trimethylxanthine + O2 + NADPH + H+	i.e. caffeine
1.14.13.128	7-methylxanthine + O2 + NADH + H+	immediate degradation via the NdmCDE complex
1.14.13.128	more	no activity toward caffeine or theobromine
1.14.13.128	7-methylxanthine + O2 + NAD(P)H + H+	part of the caffeine degradation pathway in Pseudomonas putida

Results 1 - 10 of 13

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Release 2023.1 (January 2023)