EC Number   |
Natural Substrates |
|---|
   6.3.4.10 | ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] |
- |
| 6.3.4.10 | ATP + biotin + apo-[propionyl CoA carboxylase] |
- |
| 6.3.4.10 | ATP + biotin + apo-[propionyl-CoA carboxylase] |
- |
| 6.3.4.10 | ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] |
- |
| 6.3.4.10 | ATP + biotin + apocarboxylase |
- |
| 6.3.4.10 | more |
although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview |
| 6.3.4.10 | ATP + biotin + histone H4 |
biotinylation at Lys12 especially in telomeric repeats, overview |
| 6.3.4.10 | more |
holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps |
| 6.3.4.10 | more |
holocarboxylase synthetase, HCS, catalyzes the binding of biotin to lysines in carboxylases and histones in two steps. First, HCS catalyzes the synthesis of biotinyl-5'-AMP, and second, the biotinyl moiety is ligated to lysine residues, binding structure, modelling, overview |
| 6.3.4.10 | ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] |
its deficiency causes biotin-responsive multiple carboxylase deficiency in humans |
