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<< < Results 11 - 20 of 29 > >>
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EC Number Natural Substrates Commentary (Nat. Sub.)
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14more role of splice variant GNE1 in basic supply of cells with sialic acids, whereas GNE2 and GNE3 may have a function in finetuning of the sialic acid pathway. No significant differences in activities of splice variants mGNE 1 and mGNE2
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14more GNE interacts with proteins involved in the regulation of development, e.g. the transcription factor promyelotic leukemia zinc finger protein, which might play a crucial role in the hereditary inclusion body myopathy. GNE is regulated by a variety of biochemical means, including tetramerization promoted by the substrate UDP-GlcNAc, phosphorylation by protein kinase C and feedback inhibition by CMP-Neu5Ac, which is defect in the human disease sialuria. Multienzyme complexes of GNE with the other enzymes of the sialic acid biosynthesis pathway, either close to the Golgi CMP sialic acid transporter or in particular with the nuclear localized CMP-sialic acid synthetase, are possible
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14more GNE interacts with proteins involved in the regulation of development, e.g. the transcription factor promyelotic leukemia zinc finger protein, which might play a crucial role in the hereditary inclusion body myopathy. GNE is regulated by a variety of biochemical means, including tetramerization promoted by the substrate UDP-GlcNAc, phosphorylation by protein kinase C and feedback inhibition by CMP-Neu5Ac. Multienzyme complexes of GNE with the other enzymes of the sialic acid biosynthesis pathway, either close to the Golgi CMP sialic acid transporter or in particular with the nuclear localized CMP-sialic acid synthetase, are possible
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-GlcNAc biosynthesis of sialic acid
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-GlcNAc biosynthetic pathway of sialic acid
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-GlcNAc sialic acid biosynthetic pathway
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-GlcNAc + H2O biosynthesis of sialic acids
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-N-acetyl-alpha-D-glucosamine -
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-N-acetyl-alpha-D-glucosamine allosteric regulatory mechanism, which involves direct interaction between one substrate molecule in the active site and another in the allosteric site
Show all pathways known for 5.1.3.14Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.14UDP-N-acetyl-D-glucosamine first step of sialic acid biosynthesis
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