EC Number   |
Natural Substrates |
|---|
   3.5.1.15 | N-acetylaspartic acid + H2O |
- |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
enzyme deficiency causes the Canavan disease, an autosomal-recessive neurodegenerative disorder |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
enzyme deficiency, due to mutations of aspartoacylase II, causes the Canavan disease, which is associated with optical neuropathy |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
enzyme mutations cause the Canavan disease |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
hydrolysis of N-acetylaspartic acid is important to maintain healthy neurons, the enzyme is upregulated in duodenum of obesity-induced diabetic mice, which might be responsible for diabetic neuropathy, overview |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
restoration of deficient enzyme activity by enzyme expression in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease, which is caused by elevated levels of N-acetylaspartic acid, NAA, neuronal expression of ASPA can compensate for NAA-mediated neuronal hyperexcitation, but not for oligodebdrocyte dysfunciton, overview |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
the enzyme is involved in negative regulation of brain-derived neurotrophic factor, BDNF, and timing of postnatal oligodendrogenesis, overview |
| 3.5.1.15 | N-acetylaspartic acid + H2O |
enzyme mutations cause the Canavan disease and type 2 diabetes |
