EC Number   |
Natural Substrates |
|---|
   3.4.22.56 | ICAD + H2O |
activity of caspase-activated deoxyribonuclease, CAD, is affected by the caspase 3-mediated cleavage of the CAD inhibitor, ICAD |
| 3.4.22.56 | mammalian sterile 20-like kinase 1 + H2O |
i.e. Mst1. Caspase 3 preferentially activates extracellular signal-regulated kinase preferentially through 36000 Da cleaved forms of Mst1. The 36000 Da form of Mst1 selectively phosphorylates extracellular signal-regulated kinase |
| 3.4.22.56 | Mcl-1 + H2O |
antiapoptotic protein. Caspase-3 -mediated Mcl-1 downregulation appears to be responsible for the pro-apoptotic effects of EXEL-0862 on FIP1L1-PDGFRalpha-expressing cells |
| 3.4.22.56 | MDM2 oncoprotein + H2O |
because MDM2 functions as a negative regulator of the p53 tumor suppressor and because p53 induces apoptosis in response to a variety of stimuli, this cleavage of MDM2 by CPP32-like proteases may result in deregulation of p53 and contribute directly to the process of apoptotic cell death |
| 3.4.22.56 | more |
characterization of 14 natural zebrafish caspase-3 substrates |
| 3.4.22.56 | more |
emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells |
| 3.4.22.56 | more |
interaction of Hsp27 with the caspase-3 prodomain inhibits the second proteolytic cleavage necessary for caspase-3 activation |
| 3.4.22.56 | more |
activated caspase-3 in irradiation-induced microglia death. This age-dependent irradiation-induced loss of microglia likely affects both the response to irradiation and further brain development, overview |
| 3.4.22.56 | more |
activation of caspase-3, an executioner caspase, plays a key role in the apoptotic cascade |
| 3.4.22.56 | more |
active caspase-3 is involved in apoptosis in epithelial cells of the intestine |
