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Results 21 - 24 of 24

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.5.1.59	geranylgeranyl diphosphate + Rho-cysteine	-
2.5.1.59	geranylgeranyl diphosphate + Rho10-cysteine	-
2.5.1.59	geranylgeranyl diphosphate + RhoA GTPase-cysteine	-
2.5.1.59	more	the enzyme modifies proteins by attaching a 20-carbon isoprenoid group to a cysteine residue near the C-terminus of a target protein. The enzyme requires a C-terminal Ca1a2X sequence on its substrates, with the a1, a2, and X residues serving as substrate-recognition elements for GGTase-I. Crystallographic structures of rat GGTase-I show a tightly packed and hydrophobic a2 residue binding pocket, consistent with a preference for moderately sized a2 residues in GGTase-I substrates, peptide substrate structure-activity relationship, overview. Identification of specific active-site residues within rat GGTase-I involved in substrate recognition

Results 21 - 24 of 24

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Release 2023.1 (January 2023)