EC Number |
Natural Substrates |
---|
2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
the enzyme may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in expression of sialyl Lewis X and Lewis X/SSEA-1 antigens. It may be involved in blood group Lewis determination |
2.4.1.65 | GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme |
2.4.1.65 | more |
the strong correlation between the promoter activity of the FUT III gene and the high expression of sialyl Le(a) observed in different colon carcinoma cell lines seems to conform the important regulatory role of FUT3 in the synthesis of sialyl Le(a) |