EC Number   |
Natural Substrates |
|---|
    2.1.3.3 | carbamoyl phosphate + L-ornithine |
ornithine transcarbamylase deficiency is the most common inherited disorder of the urea cycle and is transmitted as an X-linked trait, defects in the OTC gene, especially at clusters of the substrate binding sites, cause a block in ureagenesis resulting in hyperammonemia, which can lead to brain damage and death |
| 2.1.3.3 | carbamoyl phosphate + L-ornithine |
there is no preferential partitioning of carbamoyl phosphate between the arginine and pyrimidine biosynthetic pathways. Channeling must occur during the dynamic association of coupled enzymes pairs |
| 2.1.3.3 | carbamoyl phosphate + L-ornithine |
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized |
| 2.1.3.3 | carbamoyl phosphate + L-ornithine |
catalyzes the sixth step in arginine biosynthesis |
| 2.1.3.3 | more |
involved in arginine metabolism |
| 2.1.3.3 | more |
key protein involved in the degradation of arginine during malolactic fermentation |
| 2.1.3.3 | more |
Lmo0036 is an ornithine carbamoyltransferase and also a putrescine carbamoyltransferase, EC 2.1.3.6, catalysing reversible ornithine and putrescine carbamoyltransfer reactions |
