EC Number   |
Natural Substrates |
|---|
    1.17.1.8 | 2,3-dihydrodipicolinate + NAD(P)H |
essentially involved in cell wall synthesis |
| 1.17.1.8 | 2,3-dihydrodipicolinate + NAD(P)H |
repressed by lysine |
| 1.17.1.8 | 2,3-dihydrodipicolinate + NAD(P)H |
second step in the biosynthesis of meso-diaminopimelate, a bacterial cell wall component, and is involved in L-lysine biosynthesis |
| 1.17.1.8 | 2,3-dihydrodipicolinate + NAD(P)H |
enzyme is a part of the biosynthetic pathway leading to meso-diaminopimelic acid and L-lysine in bacteria and higher plants |
| 1.17.1.8 | dihydrodipicolinate + NADH + H+ |
substrate dihydrodipicolinate is instable |
| 1.17.1.8 | more |
DHDPR accepts (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid as true substrate rather than dihydrodipicolinate, suggesting that DHDPR catalyzes an overall deoxygenation reaction, likely by a dehydratase-reductase route, substrate specificity, overview. A critical role is played by residue His 159 in the catalytic mechanism of DHDPR. Replacement of this residue with an alanine or a glutamine is reported to result in a 150-200fold reduction in catalytic rate as well as a 6fold increase in KM. His 159 has been proposed to act as a general acid during catalysis, providing the proton required after hydride addition. No activity with beta-hydroxypyruvate and 3-fluoropyruvate |
