EC Number   |
Metals/Ions |
Reference |
|---|
   2.1.1.246 | Co2+ |
required, the apoprotein reacts with zinc or cobalt to the fully active holoenzyme |
717562 |
| 2.1.1.246 | Co2+ |
Zn2+ can be substituted by Co2+ |
717561 |
| 2.1.1.246 | more |
Zn21 or Co21 are required for MtaA activity, Zn2+ can be replaced by Co2+ but not by Mg2+, the kinetics of activation by Co2+ being similarily slow. About 1 mol of transition metal is bound per mol of protein. The role of the transition metal in MtaA is to lower the microscopic pKa of the thiol group of coenzyme M by coordination to the zinc, and thus to increase its nucleophilicity for methyl group attack, pKZn2+ of MtaA is over 15 |
717562 |
| 2.1.1.246 | Zn2+ |
- |
717753 |
| 2.1.1.246 | Zn2+ |
1 mol per mol of enzyme, required, the apoprotein reacts with zinc or cobalt to the fully active holoenzyme |
717562 |
| 2.1.1.246 | Zn2+ |
dependent on, kinetics, overview |
485665 |
| 2.1.1.246 | Zn2+ |
dependent on, wild-type MtaA has a zinc content of 0.91 mol/mol, binding structure, overview |
717563 |
| 2.1.1.246 | Zn2+ |
Mta contains 1 mol Zn2+ per mol of enzyme, Zn2+ can be substituted by Co2+ |
717561 |
| 2.1.1.246 | Zn2+ |
required |
717559 |
