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Metals/Ions
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2.1.1.224
Fe2+
4Fe-4S cluster. Fe-S clusters are of structural, as well as functional, importance to Cfr. Radical-SAM enzymes use an Fe-S cluster to generate the 5'-deoxyadenosyl radical from SAM, enabling them to modify intrinsically unreactive centres such as adenosine C8. Anaerobic purification from Azotobacter vinelandii Cfr
720968
2.1.1.224
Fe2+
Clostridioides difficile Cfr contains an additional Cys-rich C-terminal domain that binds a mononuclear Fe2+ ion in a rubredoxin-type Cys4 motif. The rate of turnover is decreased upon disruption of the Fe2+-binding site by Zn2+ substitution or ligand mutation
758141
2.1.1.224
Fe-S-clusters
contains a 4Fe-4S cluster. Radical-SAM enzymes contain a [4Fe-4S]+ cluster that is coordinated by the three conserved cysteine thiolate side chains in the CX3CX2C motif and one molecule of S-adenosyl-L-methionine
705983
2.1.1.224
Mg2+
required
718587
,
755810
,
758141
2.1.1.224
Iron
the enzyme requires an intact [4Fe-S] cluster for catalysis
704203
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