EC Number   |
Metals/Ions |
Reference  |
|---|
    1.13.11.34 | Ca2+ |
the enzyme is activated by a Ca2+-mediated translocation to membranes |
658043 |
| 1.13.11.34 | Ca2+ |
5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+ |
659654 |
| 1.13.11.34 | Ca2+ |
5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+. Ca2+ and 5-lipoxygenase phosphorylation seem to be required for arachidonic acid-induced 5-lipoxygenase product formation |
659654 |
| 1.13.11.34 | Ca2+ |
0.1 mM |
676811 |
| 1.13.11.34 | Mg2+ |
5 mM activates 5LO in vitro in the presence of PC |
676811 |
| 1.13.11.34 | Ca2+ |
- |
684399, 688512, 689841 |
| 1.13.11.34 | Ca2+ |
activates |
684672, 704997, 711134 |
| 1.13.11.34 | Fe2+ |
isoflavones reduce active state iron to ferrous state and prevent the activation of the resting enzyme |
684672 |
| 1.13.11.34 | Mg2+ |
- |
689841 |
| 1.13.11.34 | Ca2+ |
activates, Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein, FLAP |
689872 |
