EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
    2.1.1.37 | chloroplast |
- |
GO:0009507 AmiGO QuickGO |
658828 |
| 2.1.1.37 | chromatin |
the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner |
GO:0000785 AmiGO QuickGO |
703364 |
| 2.1.1.37 | chromatoid |
- |
- |
734682 |
| 2.1.1.37 | cytoplasm |
DNMT1 |
GO:0005737 AmiGO QuickGO |
706073 |
| 2.1.1.37 | cytoplasm |
during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos |
GO:0005737 AmiGO QuickGO |
703545 |
| 2.1.1.37 | cytoplasm |
subcellular localization of DNMT1 can be altered by the addition of IL-6, increasing the rate of nuclear translocation of the enzyme from the cytosolic compartment. The mechanism of nuclear translocation of DNMT1 is greatly enhanced by phosphorylation of the DNMT1 nuclear localization signal (NLS) by PKB/AKT kinase |
GO:0005737 AmiGO QuickGO |
685922 |
| 2.1.1.37 | heterochromatin |
both Tdg and Dnmt3b are colocalized to heterochromatin |
GO:0000792 AmiGO QuickGO |
705118 |
| 2.1.1.37 | more |
if DNA methylation occurs in plastids, is unlikely to play a role in transcriptional regulation |
- |
705744 |
| 2.1.1.37 | nucleus |
- |
GO:0005634 AmiGO QuickGO |
485275, 485278, 485290, 485305, 700956, 702105, 702212, 702694, 703146, 703228, 703330, 703987, 705118, 705915 |
| 2.1.1.37 | nucleus |
DNA MTase is enriched in nuclei |
GO:0005634 AmiGO QuickGO |
706274 |
