EC Number   |
Inhibitors |
Structure  |
|---|
    7.1.2.1 | more |
proton pump interactor (PPI1) is unable to suppress the auto-inhibitory action of the enzyme C-terminus, but further enhances the activity of the enzyme whose C-terminus has been displaced by low pH or by fusicoccin-induced binding of 14-3-3 proteins |
 |
| 7.1.2.1 | more |
not inhibitory: SCH28080 |
|
| 7.1.2.1 | more |
not inhibitory: Ni2+ |
|
| 7.1.2.1 | more |
inhibitor screening, overview |
|
| 7.1.2.1 | more |
both inhibitors, iejimalides A and B, sequentially neutralize the pH of lysosomes, induce S-phase cell-cycle arrest, and trigger apoptosis in MCF-7 cells, overview |
|
| 7.1.2.1 | more |
ebselen is at least 10fold more potent as antifungal compound compared the azoles fluconazole, itraconazole, and ketoconatzole, and as amphotericin B |
|
| 7.1.2.1 | more |
not inhibited by nitrate, azide, and molybdate |
|
| 7.1.2.1 | more |
not inhibited by azide and nitrate |
|
| 7.1.2.1 | more |
phenylglyoxal does not inhibit enzyme activity; phenylglyoxal does not inhibit enzyme activity; phenylglyoxal does not inhibit enzyme activity |
|
| 7.1.2.1 | ATP |
competitive inhibitor, the enzyme activity decreases in the presence of Mg2+-free ATP. ATP inhibition also occurs at pH 7.5. Upon increasing Mg2+ concentration from 5 mM to 15 mM, the decrease in ATPase activity at high ATP concentration is prevented |
  |
