EC Number   |
Inhibitors |
Structure  |
|---|
   4.2.3.6 | more |
identification of active site residues by site-directed mutagenesis |
 |
| 4.2.3.6 | Mn2+ |
0.01 mM, can partially replace Mg2+, inhibition at higher concentration |
  |
| 4.2.3.6 | diphosphate |
PPi |
|
| 4.2.3.6 | (7R)-(E)-6,7-dihydrofarnesyl diphosphate |
- |
|
| 4.2.3.6 | (7S)-(E)-6,7-dihydrofarnesyl diphosphate |
modestly competitive |
|
| 4.2.3.6 | farnesyl diphosphate analogs |
- |
|
| 4.2.3.6 | farnesyl diphosphate analogs |
10-fluorofarnesyl diphosphate is the most effective competitive inhibitor |
|
| 4.2.3.6 | 10-cyclopropylidene farnesyl diphosphate |
mechanism-based inhibitor |
|
| 4.2.3.6 | 10-fluorofarnesyl diphosphate |
- |
|
| 4.2.3.6 | benzyl triethylammonium cation |
BTAC alone does not inhibit the trichodiene synthase, 5-30 microM acts as a competitive inhibitor in the presence of 5-20 microM PPi |
|
