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EC Number Inhibitors Commentary Structure
Display the reaction diagram Show all sequences 3.7.1.112-methyl-2,4-pentane-diol MPD, competitive inhibitor, shows selective binding to the open funnel of CDH and strong binding to the active site. It contacts besides GlyA399 the apolar side chains of PheA259, TrpA285, LeuA551, LeuA487 and LeuA563 Go to the Ligand Summary Page
Display the reaction diagram Show all sequences 3.7.1.11Cyclohexane-1,2-dione substrate inhibition above 0.1 mM Go to the Ligand Summary Page
Display the reaction diagram Show all sequences 3.7.1.11more activity decreases significantly at this high ionic strength Go to the Ligand Summary Page
Display the reaction diagram Show all sequences 3.7.1.11NaCl inhibitory above 50 mM due to binding of the chloride anion in close neighborhood to the thiamine diphosphate cofactor Go to the Ligand Summary Page
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