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Results 1 - 10 of 221 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more no inhibition by matrix metalloprotease inhibitor XS309 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more [3S-[3R*,2-[2R*,2-(R*,S*)]-hexahydro-2-(2-[2-(hydroxyamino)-1-methyl-2-oxyethyl])-4-methyl-1-oxypentyl]-N-methyl]-3-pyridazinecarboxamide, i.e.XS309 is inactive at less than 0.01 mM in blocking ADAMTS-5 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more TIMP-1, TIMP-2 and TIMP-4 do not inhibit ADAMTS-5 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more not inhibited by N-TIMP-1 or TIMP-2; the general proteolytic activitiy of ADAMTS-5 as measured with carboxymethylated transferrin is unaffected by concentrations up to 1 M NaCl Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more substrate specificity of ADAMTS-5 against recombinant aggrecan, aggrecan mutants S377Q and S377T lead to aggrecan cleavage inhibition Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more lower expression level in majority of primary tumors Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more design of ADAMTS-5 inhibitors Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12more design and development for potent and selective inhibitors of ADAMTS-4 and ADAMTS-5 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12NaCl the activity is very low at or below 50 mM NaCl or above 500 mM NaCl Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12heparin - Go to the Ligand Summary Page
Results 1 - 10 of 221 > >>
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