EC Number |
Inhibitors |
Structure |
---|
3.2.1.209 | 1-deoxymannojirimycin |
10% residual activity at 0.0002 mM |
|
3.2.1.209 | 1-deoxymannojirimycin |
- |
|
3.2.1.209 | 1-deoxymannojirimycin |
trimming is inhibited preferentially by 1-deoxymannojirimycin, inhibits hydrolysis of 4-methylumbelliferyl-alpha-D-mannopyranoside |
|
3.2.1.209 | 1-deoxymannojirimycin |
found in crystal structures of the active site |
|
3.2.1.209 | 1-deoxymannojirimycin |
DMJ, inhibition of 4-methylumbelliferyl-alpha-D-mannopyranoside hydrolysis |
|
3.2.1.209 | 1-deoxymannojirimycin |
the enzyme is inhibited preferentially by 1-deoxymannojirimycin |
|
3.2.1.209 | brefeldin A |
known inhibitor of vesicle transport, ablated intracellular turnover of the radiolabeled molecules. Plus digestion with potato acid phosphatase implies that phosphorylation of ER mannosidase I is responsible for the altered electrophoretic mobility |
|
3.2.1.209 | Chloroquine |
lysosomotrophic amine capable of raising the pH of acidic intracellular compartments, added to the medium with weak inhibition |
|
3.2.1.209 | Chloroquine |
lysosomotrophic amine capable of raising the pH of acidic intracellular compartments, effect on the intracellular fate of endogenous mouse ER mannosidase I |
|
3.2.1.209 | Co2+ |
- |
|