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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more overview, development of inhibitors Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more overview on recently developed inhibitors Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more not inhibitory: okadaic acid Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more not inhibitory: pentamidine, okadaic acid, sodium fluoride up to 5 mM, EDTA up to 10 mM Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more in absence of externally added Ca2+, no effect of ethylene glycol bis(2-amino-ethylether) N,N,NĀ’,NĀ’-tetracetic acid or trifluoperazine. Not inhibitory: okadaic acid Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more inhibition data for isoforms CD45, Cdc25A, VHR; not inhibitory to PTP1B, CD45: disodium 3-(((4-methyl-3-(((2-methyl-5-((3-sulfonatophenyl)carbamoyl)phenyl)carbamoyl)amino)phenyl)carbonyl)amino)benzenesulfonate Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more enzyme is active in unstimulated or thrombin-stimulated platelets. Enzyme is not active in lysate of platelets adherent to fibrinogen Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more down-regulation of enzyme activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Y527 phosphorylation in Src, and decreases phosphorylation of focal adhesion kinase, p130 Crk-associated substrate, and extracellular signal-regulated kinase 1/2 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more EDTA, sodium tartrate, sodium fluoride, or okadaic acid have no effect on activity Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.48more the presence of the superoxide- and hydrogen peroxide-destroying enzymes superoxide dismutase and catalase has no effect on the rate of the inactivation reaction Go to the Ligand Summary Page
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