EC Number   |
Inhibitors |
Structure  |
|---|
   3.1.1.64 | more |
the distinctive apparent inhibition constants for NEM-induced inhibition of 11-cis retinyl-palmitate hydrolase and the all-trans-retinyl-palmitate hydrolase activity suggest a fundamental difference in the amino acid composition at the active site of the enzyme(s) |
 |
| 3.1.1.64 | more |
in vitro, the dark-adapted form of RGR (retinal pigment epithelium-retinal G protein receptor-opsin) inhibits, but the light-adapted form has no effect on all-trans-REH |
|
| 3.1.1.64 | more |
13,17,21-trimethyldocosa-12,16,20-trien-11-one and 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide are potent mRPE65 antagonists that inhibit 11-cis-retinal regeneration |
|
| 3.1.1.64 | more |
not inhibited by N-tert-butyl-(2-sulfophenyl)nitrone, alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone, NXY059, tert-butylhydroxylamine, and 2-methyl-2-nitrosopropane |
|
| 3.1.1.64 | more |
neither 8,11-eicosadiynoic acid nor 2-fluoropalmitic acid are selective or potent inhibitors of RPE65 |
|
| 3.1.1.64 | 1,10-phenanthroline |
dose-dependent inhibition |
  |
| 3.1.1.64 | NEM |
inhibits all-trans retinyl-palmitate hydrolase and 11-cis-retinyl-palmitate hydrolase activity of the liver enzyme, inhibits all-trans-retinyl-palmitate hydrolase activity of the pigment epithelium, 11-cis-retinyl-palmitate hydrolase activity of the pigment epithelium is unaffected |
|
| 3.1.1.64 | PMSF |
- |
|
| 3.1.1.64 | 2,2'-dipyridyl |
- |
|
| 3.1.1.64 | CHAPS |
the addition of 0.5% (w/v) CHAPS to the assay system almost completely abolishes the 11-cis-retinol formation |
|
