EC Number |
Inhibitors |
Structure |
---|
2.7.1.36 | (3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate |
- |
|
2.7.1.36 | (3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate |
- |
|
2.7.1.36 | 25-hydroxycholesterol |
expression of mevalonate kinase is regulated by sterol response element-binding protein-1, which is sensitive to the cllular concentration of 25-hydroxycholesterol. Presence of 25-hydroxycholesterol inhibits mevalonate kinase expression and subsequently its binding to luteinizing hormone receptor mRNA |
|
2.7.1.36 | 3,3-dimethylallyl diphosphate |
- |
|
2.7.1.36 | 5-diphosphomevalonate |
allosteric and potent inhibition, the molecule functions as a partial bisubstrate analogue that elicits a ternary-complex-like form of the enzyme, binding structure, overview |
|
2.7.1.36 | 5-phosphomevalonate |
product inhibition, non-competitive with ATP and mevalonate |
|
2.7.1.36 | 8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid |
- |
|
2.7.1.36 | ADP |
very weak inhibition |
|
2.7.1.36 | ADP |
product inhibition vs. ATP at concentration above 2 mM |
|
2.7.1.36 | ADP |
- |
|