EC Number   |
Inhibitors |
Structure |
|---|
   2.3.2.23 | 1-(1,3-benzothiazol-2-yl)methanamine |
i.e. EM04, about 40% inhibition of FANCD2 ubiquination |
   |
| 2.3.2.23 | 2-amino-5-phenylfuran-3-carbonitrile |
i.e. EM11, about 25% inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | 3-(2-hydroxyphenyl)pyridin-2(1H)-one |
- |
|
| 2.3.2.23 | 3-methyl-3,4-dihydroquinazolin-2(1H)-one |
i.e. EM09, about 15% inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | 4-phenyl-1,3-thiazol-2-amine |
i.e. EM17, about 60% inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | 5,6-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione |
- |
|
| 2.3.2.23 | 5-chloro-1,3-benzoxazole-2-thiol |
- |
|
| 2.3.2.23 | 6-chloro-1,3-benzoxazole-2-thiol |
- |
|
| 2.3.2.23 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
i.e. EM02, almost complete inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | CC0651 |
a small-molecule inhibitor that selectively inhibits Ube2R1, the specialized E2 for SCF E3 ligases, which builds K48-linked polyUb chains on its targets for proteasomal degradation. In a co-crystal structure of Ube2R1, Ub, and CC0651, the inhibitor is sandwiched between the E2 and Ub |
|
