EC Number   |
Inhibitors |
Structure  |
|---|
    2.2.1.1 | more |
Escherichia coli BL21-Gold(DE3) pQR711 has transketolase activity of ca. 6fold lower than JM107 pQR711 and JM109 pQR711 |
 |
| 2.2.1.1 | more |
activity of transketolase is significantly reduced in brains of alcoholic patients with Wernicke-Korsakoffs Syndrome. Reduced transketolase protein expression levels in autopsied prefrontal white and grey matter and cerebellar vermis samples from neurologically uncomplicated alcoholics and alcoholics with liver cirrhosis |
|
| 2.2.1.1 | more |
ppGpp deficiency lowers TktB activity |
|
| 2.2.1.1 | more |
oxythiamine, inhibitor of human enzyme, is not inhibitory up to 0.03 mM. Instead, oxythiamine, at this concentration, increases the rate of the reaction by 30% under the assay conditions tested. 5-benzyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one also has no inhibitory effect |
|
| 2.2.1.1 | more |
after 3 h incubation with 50 mM oxidized dithiothreitol, the activity of the enzyme bound to thiamine diphosphate and Mg2+ is almost unaffected, retaining more than 90% of the control (reduced) enzyme activity |
|
| 2.2.1.1 | ATP |
- |
  |
| 2.2.1.1 | ADP |
- |
|
| 2.2.1.1 | phosphate |
- |
|
| 2.2.1.1 | phosphate |
not |
|
| 2.2.1.1 | EDTA |
reversible by cofactors |
|
