EC Number   |
Inhibitors |
Structure |
|---|
   1.5.1.6 | more |
- |
 |
| 1.5.1.6 | tetrahydrofolate |
- |
  |
| 1.5.1.6 | Trypsin |
- |
|
| 1.5.1.6 | hydroxylamine |
0.1 M, strong inhibition |
|
| 1.5.1.6 | 5,10-dideazatetrahydrofolate |
0.4 mM, 98% inhibition, folate analog |
|
| 1.5.1.6 | N-ethylmaleimide |
1 mM or 10 mM, complete inhibition |
|
| 1.5.1.6 | tetrahydropteroylhexaglutamate |
1 mol per mol of tetrameric protein, potent product inhibitor: 0.0003 mM, 90% inhibition |
|
| 1.5.1.6 | Trypsin |
20 min, 70% inhibition, rapid but incomplete loss of dehydrogenase activity; tryptic digestion inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase activity |
|
| 1.5.1.6 | chymotrypsin |
cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity |
|
| 1.5.1.6 | Subtilisin |
cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity |
|
