EC Number |
Inhibitors |
Structure |
---|
2.7.11.10 | more |
CREB-binding protein-bound NEMO/IKKgamma inhibits IKKalpha and p65 transcriptional activities |
|
2.7.11.10 | more |
evodiamine analogue rutaecarpine does not inhibit IKK and NF-kappaB activation |
|
2.7.11.10 | more |
simvastatin inhibits the TNFalpha-induced activation of IkappaB kinase and activation of NF-kappaB in vitro and in vivo, simvastatin highly affects the whole NF-kappaB-dependent pathway of signaling, overview |
|
2.7.11.10 | more |
prolyl hydroxylase-1 negatively regulates IKKbeta, hydroxylation represses IKKbeta activity by altering protein expression or by preventing its activation through phosphorylation on S177/S181 |
|
2.7.11.10 | more |
two structurally unrelated kinase inhibitors, termed NG25 or 5Z-7-oxozeaenol, inhibit the TAK1 protein kinase, and therefore also inhibit activation of IKKalpha and IKKbeta |
|
2.7.11.10 | more |
structure-based design of IKK-2 inhibitors based on induced-fit docking into the homology model, overview |
|
2.7.11.10 | arsenite |
inhibition of IKKbeta |
|
2.7.11.10 | salicylate |
weak inhibition of IKK-2 |
|
2.7.11.10 | Wortmannin |
phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, but phosphorylation of Ser176/Ser180 is not |
|
2.7.11.10 | curcumin |
weak inhibition of IKK-2 |
|