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<< < Results 161 - 170 of 228 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain up to 67% inhibition in absence of NH4+ Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain up to 87% inhibition Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain ouabain does not affect TNF-alpha-induced mRNA expression but inhibits TNF-alpha-induced protein expression Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain complete inhibition at 0.001 mM Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the cat at 25 nM a 43% decrease in cell viability due to apoptosis and necrosis Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis.The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the rat at 0.002 mM a 43% decrease in cell viability due to apoptosis and necrosis Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain a cardiac glycoside derived from Strophanthus gratus, ouabain is deeply inserted into the transmembrane domain with the lactone ring very close to the bound K+. Low-affinity ouabain-bound state due to antagonism between ouabain and K+. The closure of the binding cavity confers a high affinity, homology model for the high affinity state, structures, overview. Binding of sugar moiety and steroid core, overveiw Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain ouabain up to 1 mM decreases silkworm ATPase activity to 42% of the maximal ATPase activity in presence of 10 mM NaCl and 30 mM KCl Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 7.2.2.13Ouabain Na+/K+-ATPase specific inhibitor Go to the Ligand Summary Page
<< < Results 161 - 170 of 228 > >>
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