EC Number |
Inhibitors |
Structure |
---|
6.3.4.15 | 2'-amino-5'-[N-(D-biotinoyl)sulfamoyl]amino-3',5'-dideoxyadenosine |
nucleoside-based inhibitor, KD value 0.627 nM |
|
6.3.4.15 | 2-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)ethyl 2,2-dimethylpropanoate |
- |
|
6.3.4.15 | 3-(2-oxo-1,3-benzoxazol-3(2H)-yl)-N-phenylpropanamide |
inhibitor identified by molecular docking, glide score -7.49, glide energy -40.64 kcal/mol |
|
6.3.4.15 | 5-chloro-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one |
not inhibitory to human enzyme at 0.08 mM |
|
6.3.4.15 | 5-methyl-3-[3-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)propyl]-1,3-benzoxazol-2(3H)-one |
- |
|
6.3.4.15 | 5-methyl-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one |
competitive inhibitor versus biotin |
|
6.3.4.15 | 5-methyl-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one |
not inhibitory to human enzyme at 0.08 mM |
|
6.3.4.15 | 9-[2'-azido-5'-O-[N-(D-biotinoyl)sulfamoyl]-2'-deoxy-beta-D-arabinofuranosyl]adenine |
nucleoside-based inhibitor, KD value 0.027 nM. Strongest binding inhibitor in series |
|
6.3.4.15 | ATP |
- |
|
6.3.4.15 | biotin acetylene |
i.e. (3aS,4S,6aR)-4-hept-6-ynyl-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one |
|