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EC Number
Inhibitors
Commentary
Structure
3.4.24.11
thiorphan-NH2
-
3.4.24.11
tris(2-carboxyethyl)phosphine
TCEP, strong inhibition
3.4.24.11
U46619
a thromboxane mimetic
3.4.24.11
UK-69,578
-
3.4.24.11
valsartan
LCZ696 comprises molecular moieties of valsartan, and of the NEP inhibitor prodrug AHU377 ((2R,4S)-5-biphenyl-4-yl-5-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester) (1:1 molar ratio). Oral administration of healthy volunteers is associated with increases in plasma cGMP, renin concentration and activity, and angiotensin II, providing evidence for NEP inhibition and angiotensin receptor blockade
3.4.24.11
valsartan
-
3.4.24.11
Z-Leu-Leu-Leu-H
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