EC Number |
Inhibitors |
Structure |
---|
2.4.1.288 | (3S,4S)-3-(1,2-dihydroxyethyl)-4-hydroxy-1-(2-phenylethyl)tetrahydrothiophenium chloride |
sulfonium ion compound as analogue of the donor substrate, uridine diphosphategalactofuranose. The compound contains moieties that mimic both galactofuranose and uridine diphosphate domains, and carries a permanent positive charge to mimic the oxocarbenium ion-like transition state. About 60% inhibition at 4 mM |
|
2.4.1.288 | (1S,2S,3S,4S,5R)-1-[(1S)-1,2-dihydroxyethyl]-4-[[(furan-2-yl)methyl]amino]bicyclo[3.1.0]hexane-2,3-diol |
UDP-Gal analogue, 82% inhibition at 4 mM |
|
2.4.1.288 | 2-[(5E)-5-[(3,4-dichlorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-(4-iodophenyl)propanoic acid |
UDP-galactopyranose mutase inhibitor, binding energy value of -8.08 kcal/mol. Compound passes the ADME evaluation and the predicted toxicity evaluation |
|