EC Number |
Activating Compound |
Reference |
---|
5.1.1.18 | ATP |
- |
662359, 704657, 705049, 727156, 747702 |
5.1.1.18 | ADP |
- |
662950 |
5.1.1.18 | ATP |
1 mM, decrease of Km-value for racemization by 85%, allosteric mechanism. Inhibitory to L-serine O-sulfate dehydration reaction |
662950 |
5.1.1.18 | GTP |
- |
662950 |
5.1.1.18 | D-serine |
up to 5fold increase in activity |
662958 |
5.1.1.18 | more |
activation of enzyme by glutamate neurotransmission involving alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors |
663242 |
5.1.1.18 | ADP |
less effective than ATP |
663268 |
5.1.1.18 | ATP |
and MG2+, up to 5fold stimulation |
663268 |
5.1.1.18 | more |
the amyloid beta-peptide and secreted forms, liberated by alpha- or beta-secretase, of beta-amyloid precursor protein induce enzyme expression and lead to elevated D-serine levels in microglia, overview |
679355 |
5.1.1.18 | more |
ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, transiently enhances the expression of the enzyme in the brain in all the brain areas, overview |
679661 |