EC Number   |
Activating Compound |
Reference  |
|---|
   3.4.24.86 | lipopolysaccharide |
- |
638985, 638989, 639002 |
| 3.4.24.86 | phorbol ester |
stimulates the TACE-mediated release of TNF-alpha from cells |
638985 |
| 3.4.24.86 | phorbol 12-myristate-13-acetate |
PMA |
638989 |
| 3.4.24.86 | phorbol 12-myristate-13-acetate |
- |
638992 |
| 3.4.24.86 | phorbol ester |
- |
638989, 638992, 638994, 638995, 639002, 639004, 639006, 639011 |
| 3.4.24.86 | N-formyl-L-methionyl-phenylalanine |
ADAM17 substrates undergo efficient turnover during extended neutrophil activation by N-formyl-L-methionyl-phenylalanine |
679641 |
| 3.4.24.86 | oxygen |
low oxygen concentrations enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region |
680846 |
| 3.4.24.86 | Tumor necrosis factor alpha |
20 ng/ml tumor necrosis factor alpha enhances TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region |
680846 |
| 3.4.24.86 | four and half LIM domain 2 protein |
four and half LIM domain 2 protein binds both ADAM-17 and the actin-based cytoskeletonand is involved in the regulation of ADAM-17 cellular localization and activity |
681031 |
| 3.4.24.86 | furin |
activates ADAM-17 |
681031 |
