EC Number   |
Activating Compound |
Reference |
|---|
   3.4.13.9 | (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
deregulates the collagen metabolism and strongly induces inhibition of collagen synthesis, but activates the enzyme accompanied by increase in the expression of b1 integrin receptor and some b1 integrin-dependent signalling proteins, e.g. Sos, MAPK ERK1and ERK2, and transcription factor NF-kB, the specific MEK/ERK inhibitor UO126 inhibits campthotecin-induced up-regulation of prolidase activity |
683612 |
| 3.4.13.9 | 8-Br-cGMP |
strong and rapid stimulation of enzyme activity by phosphorylation |
669598 |
| 3.4.13.9 | Acetylsalicylic acid |
- |
683405 |
| 3.4.13.9 | alpha-ketoglutarate |
30% activation at 0.01 mM |
683216 |
| 3.4.13.9 | apigenin-7-O-glucuronide |
stimulates the enzyme and collagen biosynthesis in osteogenesis imperfecta type I cells, overview |
683569 |
| 3.4.13.9 | Colchicine |
colchicine enhances PLD activity for Gly-L-Pro and L-Leu-L-Pro, the highest enhancement of PLD on Gly-L-Pro is 141% at 0.01 mM |
699153 |
| 3.4.13.9 | D,L-ethionine |
enhances the activity of isozyme prolidase I, D,L-ethionine strongly enhances the activity of isozyme prolidase II compared with L-ethionine |
695528 |
| 3.4.13.9 | D,L-homocysteine |
enhances the activity of isozyme prolidase I at low concentration |
695528 |
| 3.4.13.9 | D,L-homocysteine |
weakly enhances the activity of isozyme prolidase II |
695528 |
| 3.4.13.9 | D,L-methionine |
slightly enhances the activity of isozyme prolidase I at low concentration |
695528 |
