EC Number   |
Activating Compound |
Reference |
|---|
   3.1.4.53 | Calmodulin |
required, Km value 0.000057 mM |
677917 |
| 3.1.4.53 | cAMP |
binds to N-terminus and GAF domain, affinity of 0.0005 mM |
678039 |
| 3.1.4.53 | cAMP |
binds to N-terminus and GAF domain, affinity of 0.001 mM |
678039 |
| 3.1.4.53 | cGMP |
binds to N-terminus and GAF domain, affinity of 0.003 mM |
678039 |
| 3.1.4.53 | EDTA |
EDTA at 0.10 mM slightly activates PDE4 |
690423 |
| 3.1.4.53 | extract of Ginkgo biloba |
some beneficial effects of extract of Ginkgo biloba might be due to its modulating influences on cellular cyclic AMP levels via activation of membrane-bound PDE |
688524 |
| 3.1.4.53 | follicle-stimulating hormone |
stimulation |
678559 |
| 3.1.4.53 | haloperidol |
chronic treatment with 20 mg/kg clozapine increases PDE4B2 and PDE4B4 expression by 102 and 71%, respectively |
694373 |
| 3.1.4.53 | isoproterenol |
0.001 mM isoproterenol triggers a sustained, 2fold increase in PDE4 activity |
688125 |
| 3.1.4.53 | isoproterenol |
PDE4 activity is stimulated with 0.01 mM isoproterenol |
694262 |
