EC Number   |
Activating Compound |
Reference |
|---|
   2.7.7.48 | 5-chlorosalicylic acid |
2 mM, induction of RdRp gene expression |
694100 |
| 2.7.7.48 | dithiothreitol |
10 mM, required to achieve maximal polymerase activity |
758652 |
| 2.7.7.48 | Foot-and-Mouth disease virus 3B1 |
acts as primer for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptide has to be uridylated to form VpgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre |
662742 |
| 2.7.7.48 | Foot-and-Mouth disease virus 3B2 |
acts as primer for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptide has to be uridylated to form VpgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre |
662742 |
| 2.7.7.48 | Foot-and-Mouth disease virus 3B3 |
acts as primer for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptide has to be uridylated to form VpgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre |
662742 |
| 2.7.7.48 | GTP |
flaviviral RdRps require high concentrations of the second incoming nucleotide GTP to catalyze de novo template-dependent RNA synthesis. GTP stimulates de novo RNA synthesis by RdRp from Japanese encephalitis virus |
739192 |
| 2.7.7.48 | GTP |
required for de novo (primer-independent) initiation |
663225 |
| 2.7.7.48 | host factor |
hexameric host-coded protein of 12500 Da subunits is required for in vitro Qbeta RNA replication |
643349 |
| 2.7.7.48 | L-protein |
the intact L protein is essential for enzyme (RdRP) activity and optimal RNA binding. In truncated L protein constructs, enzyme activity is abrogated due to their deficiency in RNA template binding |
758571 |
| 2.7.7.48 | more |
RdRp is induced by fungal infection of Rhizoctonia solani |
694100 |
